Potential Effect of Medicinal Plants on the Prevention of Gastric Ulcer: Mechanism of Actions

Medicinal plants have been widely studied to identify plant-based anti-gastric ulcer medicines. The mechanism of gastroprotective action is important discover the potential lead compounds for drug development. All relevant articles between 2011 and 2021 focusing on Malaysian were collected analyzed understand underlying pathways. Keywords include peptic ulcer, gastric NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), Helicobacterpylori, medicinal plant, gastroprotection, antiulcer, acid secretion, cytoprotective, digestion processes applied in search engines. Twenty-two had reported based data. review concludes that could protect wall against necrotizing agents like ethanol NSAIDs. This mainly due four critical defensive mechanisms: cytoprotective barriers, regulation heat-shock protein 70 (HSP70) pro-apoptotic (BAX), antioxidant capability. mechanisms illustrated schematic diagrams better understanding.